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Acculate
Question:
I took Accolate for 2.5 months. I found that at first it started to help but then it just stagnated. I have cough variant asthma. The problem was that it has to be taken on an empty stomach—-which was VERY hard to do. Mornings were easy (but then my stomach would hurt some days) but evenings are very hard to deal with. Our lifestyle is such that we do not eat on a schedule. So after 2.5 months, we could justify to my insurance company (CIGNA) that I should switch to Singulair. Been on that for nearly a week now. After 2 months on Accolate I did notice some bruising that would come from no where (or so it seemed). That has gone away now. Good Luck—–Lynn – Hide quoted text — Show quoted text – O.K., I am about to start Accolate therapy. What are some of the most common complaints in the real world, and as opposed to what is listed in information packet that comes from the pharmacy? I am 40 year old female and I currently take Serevent, 2 xd, Theo-dur 1xd, flovent, 3, albuterol as a rescue inhaler, and I use a comboneb probably 3 to 6 times a week (This is a seasonally driven amount). Every couple of months, I find myself on prednisone 6 down to 1 therapy at 10mgs each. Accolate sound wonderful, but we all know better. What are some of the drawbacks to this drug. My attacks stopped when I was about 19 years old, not even a wheeze, nothing. Then it started all over again 4 years ago worse then ever. I did stopped my meds during this periord. So needless to say, I am hoping for another unexplained leave of absence. I appreciate any input from Accolate users. Thank you.
Response:
O.K., I am about to start Accolate therapy. What are some of the most common complaints in the real world, and as opposed to what is listed in information packet that comes from the pharmacy? I am 40 year old female and I currently take Serevent, 2 xd, Theo-dur 1xd, flovent, 3, albuterol as a rescue inhaler, and I use a comboneb probably 3 to 6 times a week (This is a seasonally driven amount). Every couple of months, I find myself on prednisone 6 down to 1 therapy at 10mgs each. Accolate sound wonderful, but we all know better. What are some of the drawbacks to this drug. My attacks stopped when I was about 19 years old, not even a wheeze, nothing. Then it started all over again 4 years ago worse then ever. I did stopped my meds during this periord. So needless to say, I am hoping for another unexplained leave of absence. I appreciate any input from Accolate users. Thank you.
Response:
I found Acculate a pain to take. If you don’t take it on an empty stomach it isn’t absorbed. It is also taken twice a day which for me was difficult to schedule around meal time and my regular life. I take Singulair now and it is a magic bullet, as far as breathing is concerned but I think that it has made me gain wt. Wt. gain isn’t one of the side effects listed and when I asked my doctor he said that none of his other patients on Singulair complained about wt gain. He did say that he would ask the drug rep. about it. In the mean time I have continued to take it before I go to bed, and started a more wt. controlling eating plan ( no more chips, no more donuts, limited chocolate) and more consistent exercise. My advice is start out on Singulair and save yourself the hassle of Acculate. Take care, Pam
Response:
He would be better off asking the drug reps of one of Accolade’s competitors. The Accolate drug rep is unlikely to attribute any adverse effects to his drug that he doesn’t have to. Those guys are whores who lie constantly to sell their products. — Good Luck, CBI, M.D. – Hide quoted text — Show quoted text – I found Acculate a pain to take. If you don’t take it on an empty stomach it isn’t absorbed. It is also taken twice a day which for me was difficult to schedule around meal time and my regular life. I take Singulair now and it is a magic bullet, as far as breathing is concerned but I think that it has made me gain wt. Wt. gain isn’t one of the side effects listed and when I asked my doctor he said that none of his other patients on Singulair complained about wt gain. He did say that he would ask the drug rep. about it. In the mean time I have continued to take it before I go to bed, and started a more wt. controlling eating plan ( no more chips, no more donuts, limited chocolate) and more consistent exercise. My advice is start out on Singulair and save yourself the hassle of Acculate. Take care, Pam
Response:
- Hide quoted text — Show quoted text – O.K., I am about to start Accolate therapy. What are some of the most common complaints in the real world, and as opposed to what is listed in information packet that comes from the pharmacy? I am 40 year old female and I currently take Serevent, 2 xd, Theo-dur 1xd, flovent, 3, albuterol as a rescue inhaler, and I use a comboneb probably 3 to 6 times a week (This is a seasonally driven amount). Every couple of months, I find myself on prednisone 6 down to 1 therapy at 10mgs each. Accolate sound wonderful, but we all know better. What are some of the drawbacks to this drug. My attacks stopped when I was about 19 years old, not even a wheeze, nothing. Then it started all over again 4 years ago worse then ever. I did stopped my meds during this periord. So needless to say, I am hoping for another unexplained leave of absence. I appreciate any input from Accolate users. Thank you.
I took Accolate for four months. It didn’t seem to help much, but I had no obvious side effects. Then one day my pulmonologist recommended doing some blood tests to check my liver function tests, based on some new information he had just read. We were both surprised to find that the liver function tests were all quite elevated!! Needless to say, I immediately stopped the Accolate and noticed no change in my asthma symptoms. The liver tests took six months to return to normal (they had been normal prior to starting the Accolate). Make sure your doctor checks your liver funtion tests periodically, in spite of what the literature may say to the contrary. Jeff.
Response:
O.K., I am about to start Accolate therapy. What are some of the most common complaints in the real world, and as opposed to what is listed in information packet that comes from the pharmacy? I am 40 year old female and I currently take Serevent, 2 xd, Theo-dur 1xd, flovent, 3, albuterol as a rescue inhaler, and I use a comboneb probably 3 to 6 times a week (This is a seasonally driven amount). Every couple of months, I find myself on prednisone 6 down to 1 therapy at 10mgs each. Accolate sound wonderful, but we all know better. What are some of the drawbacks to this drug. My attacks stopped when I was about 19 years old, not even a wheeze, nothing. Then it started all over again 4 years ago worse then ever. I did stopped my meds during this periord. So needless to say, I am hoping for another unexplained leave of absence. I appreciate any input from Accolate users.
I considered Accolate (since my HMO prefers it cuz its cheaper than Singulair) but went with Singulair instead after my doctor wrote a justification; because Accolate interferes with another drug I take, TheoDur, and tends to upset my stomach as I’m on niacin for cholesterol. Here’s the complete PI: http://www.usa.zeneca.com/pharm/pibs/pib_accolate.htm I see you are taking TheoDur (theophylline); this should provide justification for your medical insurance to pay the higher price for Singulair, which doesn’t have an interaction with theophylline. [Singulair also has advantage of once/day dosing and stomach doesn't have to be empty] Quoting from the Accolate PI: "ADVERSE REACTIONS Rarely, elevations of one or more liver enzymes have occurred in patients receiving ACCOLATE in controlled clinical trials. Rare cases of patients experiencing increased theophylline levels with or without clinical signs or symptoms of theophylline toxicity after the addition of ACCOLATE to an existing theophylline regimen have been reported. The mechanism of the interaction between ACCOLATE and theophylline in these patients is unknown and not predicted by available in vitro metabolism data and the results of a clinical drug interaction study (see CLINICAL PHARMACOLOGY, Drug Interactions). " more info on singulair at www.singulair.com Ellis
Response:
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