My Crohn's and Colitis Blog » Bronchial Asthma Treatment » ms in the family?
ms in the family?
Question:
Someone had mentioned that they read that 4% of people with MS have it in their family. I have read that the percentage is much higher, about 20%. That is why there is the theory about genetic predispositions (not heredity). RN
Response:
In article <19970226004301.TAA16…@ladder02.news.aol.com
,
rnand…@aol.com (RNandCPA) wrote:
Someone had mentioned that they read that 4% of people with MS have it in their family. I have read that the percentage is much higher, about 20%. That is why there is the theory about genetic predispositions (not heredity). RN
In the U.K., the recently accepted estimates are expressed differently: The offspring are four times more likely to experience some form of demyelination than the offspring of unaffected people. (For the record, this is still pretty low.) The proposed genetic theory (in the U,K.) is that there are possibly three of four susceptible genes (of Scandinavian or North British origin) that can be affected (in some people) by a viral infection. George
Response:
pastu…@blackboard.com (Andrew Pastuszak) wrote:
I’ve done some reading on MS which all say that 4% of people with MS have it in the family. What I can’t find are stats concerning the chances of it
No one in my family has MS (nor any other other autoimune diseases). My husband (who also has MS) has a cousin with MS. As far as genetics — what I’ve read indicates that there is a genetic link, but not strictly heridetary (sort of like an inherited tendency, but requiring an external trigger). A brief article in WOMS (www.ifmss.org.uk) suggested that the tendency was spread by the Vikings. I do have Viking ancestry (highland Scot). Other things I’ve read said you have to grow up someplace cold — I’m one of the few people in my US family tree to grow up in a cold place (I lived in Michigan for 11 years, but then we moved to Florida so even my sisters didn’t spend much time there). Z +————————————————————————+ + Carolyn C. Zimmer | "I’ve been warped by the rain, | + Duluth, GA | driven by the snow, I’m drunk and dirty, | + cczim…@mindspring.com | don’t you know, But I’m still…willin’" | + STANDARD DISCLAIMER | Lowell George | +————————————————————————+
Response:
I am one of six children. My mom had ms, she died 7 years ago today. She went to a dr. in Germany years ago and he said there wasn’t much chance of us kids having ms but the one to watch would be the son, 5 girls one boy. well I was the one. My brother is 11 months older than me.
Response:
Have to add my .02 to this discussion of ms in the family. I’m the eldest of 3 girls and 1 boy. My brother is 17 years my junior and has ms, as do I. One sister has Epstein Barr and the other sister has severe scoliosis of the spine. She’s 15 years my junior and the other sister is 3 years my junior. Now my daughter is showing ms signs and went blind the day after Christmas. She’s had ms symptoms for quite a while and they want to do an MRI on her. I feel awful about it. Hope I didn’t cause this to happen in my children. Love, Stelle
Response:
Chris/Andrew, I have MS and my Mom also has it. Ironically we both came down with it in our late 20’s, identical symptoms, optic neuritis, etc. I too have been in search of answers. I have read from several sources that the subceptibility is hereditary though. But what’s that supposed to mean? Also in taking a poll from my MS support group, we found that we were all raised in familis of heavy milk drinkers and all had relatives with diabetis. A scientist at our University claims the diabetis gene is next to the suspected genes involved in ms. Interesting. I too have called the MS Association and have not heard back from them either. I wish they would get their butts in gear and respond to us. I saw a publishing of who to contact awhile back that was doing a study of the incidence in families. Then I lost it, but will still try to locate it. I know it is still in my house as I am a pack rat! I would be very interested in learning about others with our experience. Let me know further what you may find and I will do the same. Best wishes Lyndsy Struck – Hide quoted text — Show quoted text -Andrew Pastuszak wrote:
I’ve done some reading on MS which all say that 4% of people with MS have it in the family. What I can’t find are stats concerning the chances of it happening with siblings. I called the local MS chapter and they don’t have any info either. I got diagnosed about a month after my brother. He is two years older than me. I have also asked the local chapter about what they call "clusters." I know of seven people in my home town out of about 12,000 and am told by others that there are more around town. The MS Society has not gotten back to me yet. If anyone has any info I’d really appreciate it. I don’t know why this bothers me so much, but it does. I guess I ‘m hoping if they figure out how it happened to two in the same family they can figure out how this happened at all. It is also interesting that one of our sisters is going to talk to her doctor about testing next week. That would make three out of nine kids with MS. Chris
Response:
I’m 59, male, dx with CP MS in 3/95. About a year ago, my brother e-mailed to remind me that our grandmother’s sister had maybe had MS, and he put me in touch with that woman’s daughter. Turns out that I’m at least the FOURTH successive generation to have MS. Began in North Scotland (old Banffshire), when my great-grandfather (my father’s mother’s father) had late onset MS and died at age 51 in 1891, with 11 children! Of his children, one daughter (my paternal grandmother’s sister) had late onset MS in her 40s, and was bedridden from about 1941 to 1965. One or two of her nephews/nieces had MS; no details. And now me. My three sons are blotting out the possibility they might be carrying the gene as well–I hope not. And their children …. One of whom I just went to see play in a high-school ice hockey game. Sectional semi-finals. They won, 5-2, beating Auburn. Now on to the winners of Oswego vs. Rome tomorrow. (This fortunate kid is my second son’s stepson, so he doesn’t have the terrible gene, thank goodness.) God, it’s difficult climbing steep steps in cold ice arenas. –david
Response:
no one in my family has ms though my maternal grandmother died of Parkinson’s, furthermore she came over from Poland. to keith I’m glad you found us. i tend to have multiple crisis, MS arthritis, necrotic bone with such severe pain, asthma one thing after another, especially this last 12 months. I’m hanging in there, but it’s hard going. At 12:10 PM 2/9/97 GMT, you wrote: – Hide quoted text — Show quoted text -
In message <5dk07t$…@surf3.p3.net pastu…@blackboard.com (Andrew Pastuszak) writes: I’ve done some reading on MS which all say that 4% of people with MS have it in the family. What I can’t find are stats concerning the chances of it happening with siblings. snip Chris My wife has had MS for over 10 years. She has five brothers and sisters, one brother also has MS. As a side point my wife also has Crohn’s disease and suffers from brittle bones. We seem to lurch from one crisis to the next. Is she just unlucky or are multiple ailments common amongst MS sufferers? I apologise if this has been covered previously but have only just found the NG. keith l
——————————————————- ———– There is always a little piece /_____/ of heaven in the disaster-area! ==-=-/ o o =-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-======= === ( == ^ == ) === Luv Susan === ) ( == === ( ) ===-( ( ) ( ) )=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-== == (__(__) _(__)__) s_guzie…@conknet.com – Hide quoted text — Show quoted text -
———————————————————————
Response:
Keith Landless wrote:
(snip)
As a side point my wife also has Crohn’s disease and suffers from brittle bones. We seem to lurch from one crisis to the next. Is she just unlucky or are multiple ailments common amongst MS sufferers? I apologise if this has been covered previously but have only just found the NG. keith l
Keith, Welcome to the group, and condolences on your need for it. I don’t think your wife is particularly unlucky to have more ailments than MS to deal with, but she may be a bit unlucky in how severe the other stuff is. Since I’ve been following the NG (Oct. 1996), no one has phrased a question about multiple ailments the way you do. There have been discussions about MS and cancer; MS and lupus; MS and other autoimmune diseases in general; MS and ADD; and probably others that I’m not thinking of right now. A lot of people with MS have other medical issues also, but they aren’t always the same medical issues. My wife has been diagnosed with MS for five years, and may have had it for 25 years. She has had a number of health problems within the past decade. Some are clearly related to the MS, some are clearly unrelated, and some we’re not sure about. Our biggest ongoing health concerns for her are MS; ADD (not related to MS, we think); bronchial asthma (not sure whether it’s MS-related); and an overweight problem (not initially MS-related, but MS makes it harder to correct). None of her non-MS or maybe-MS problems are as serious as what your wife faces. Your post is the first I’ve heard of someone with both MS and Crohn’s disease, but I think someone else mentioned brittle bones once. The feeling of lurching from one crisis to another sounds awfully familiar to me, and will likely sound familiar to others also. I wish you well in dealing with the crises. Kevin — kclnf…@frontiernet.net It is impossible to make anything foolproof, because fools are so ingenious. — Eleventh Corollary to Murphy’s Law
Response:
In article <5dk07t$…@surf3.p3.net
, pastu…@blackboard.com (Andrew
Pastuszak) wrote:
I’ve done some reading on MS which all say that 4% of people with MS have it in the family. What I can’t find are stats concerning the chances of it happening with siblings. I called the local MS chapter and they don’t have any info either. I got diagnosed about a month after my brother. He is two years older than me. I have also asked the local chapter about what they call "clusters." Chris
chris, ms (i’m told) is not hereditary nor does it run in families. i’ve had ms since ‘87 and my mother also has ms. i was dx before her. mom went to different drs for different sypmtoms and finally when drs did mri on her neck for surgery drs also took mri of part of brain peggy
Response:
You know I read all this stuff in here where most MS’ers had mono or chicken pox or something at one time and now where a lot of us have MS in the family. I have not had any childhood disease of any kind and nobody in my family has MS, Lupus or any other kind of disease. I hate to put a dent in the stats but I don’t think any of this has to do with a person chance of getting MS.
Response:
In message <5dk07t$…@surf3.p3.net
pastu…@blackboard.com (Andrew Pastuszak) writes:
I’ve done some reading on MS which all say that 4% of people with MS have it in the family. What I can’t find are stats concerning the chances of it happening with siblings.
snip
Chris
My wife has had MS for over 10 years. She has five brothers and sisters, one brother also has MS. As a side point my wife also has Crohn’s disease and suffers from brittle bones. We seem to lurch from one crisis to the next. Is she just unlucky or are multiple ailments common amongst MS sufferers? I apologise if this has been covered previously but have only just found the NG. keith l
Response:
My brothers are ok, but I have a 1st cousin with MS. Elaine ENewman…@worldnet.att.net Andrew Pastuszak <pastu…@blackboard.com
wrote in article
<5dk07t$…@surf3.p3.net
…
– Hide quoted text — Show quoted text -
I’ve done some reading on MS which all say that 4% of people with MS have
it
in the family. <snip this happened at all. It is also interesting that one of our sisters is
going
to talk to her doctor about testing next week. That would make three
out of
nine kids with MS. Chris
Response:
Chris, There are only five children in my family. The first born is going down the "Al" trail (losing her mind). The second is gay. The third and fourth has MS. The fifth is all right, butI think she’s a butt-hole. I’ve learned to live with it all. To take life the way it’s dealt to me. And not to worry about things that could have been. Richard Nagel VAH-4 & VAQ-131 1966-70 krycek "Never deprive someone of hope; it might be all they have." ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Over 50 but still going up hill. ********************************
Response:
Andrew Pastuszak wrote:
I’ve done some reading on MS which all say that 4% of people with MS have it in the family. What I can’t find are stats concerning the chances of it happening with siblings.
Fairly recent research has concluded that there is a genetic susceptibility link with MS. The following is a summary found on the NMSS web site. More details are at http://www.nmss.org/msinfo/current_research/updates/RMP9630.html What I see on the NMSS site isn’t enough to figure a statistical chance of siblings having MS, but it might give you some names to write if you want to pursue it further. Start quote Date: August 2, 1996 FINDINGS FROM FOUR STUDIES ON MS SUSCEPTIBILITY GENES A team of researchers funded by the National Multiple Sclerosis Society, and three other groups of scientists, published initial results from their studies on genetic susceptibility to multiple sclerosis in the August 1996 issue of the scientific journal Nature Genetics. These studies confirm that susceptibility to multiple sclerosis results from the actions of a number of genes, no one of which has an overwhelming effect. Further research will be necessary to identify the exact genes involved, and to determine how they cooperate to make a person susceptible to multiple sclerosis. End quote Kevin — kclnf…@frontiernet.net It is impossible to make anything foolproof, because fools are so ingenious. — Eleventh Corollary to Murphy’s Law
Response:
I’ve done some reading on MS which all say that 4% of people with MS have it in the family. What I can’t find are stats concerning the chances of it happening with siblings. I called the local MS chapter and they don’t have any info either. I got diagnosed about a month after my brother. He is two years older than me. I have also asked the local chapter about what they call "clusters." I know of seven people in my home town out of about 12,000 and am told by others that there are more around town. The MS Society has not gotten back to me yet. If anyone has any info I’d really appreciate it. I don’t know why this bothers me so much, but it does. I guess I ‘m hoping if they figure out how it happened to two in the same family they can figure out how this happened at all. It is also interesting that one of our sisters is going to talk to her doctor about testing next week. That would make three out of nine kids with MS. Chris
Response:
Related Posts
Categories: Bronchial Asthma Treatment | 
No Comments »