My Crohn's and Colitis Blog » Bronchial Asthma Treatment » Bacterial infection as an important triggering factor in bronchial asthma. [MEDLINE]
Bacterial infection as an important triggering factor in bronchial asthma. [MEDLINE]
Question:
Title : Bacterial infection as an important triggering factor in bronchial asthma. Author : Oehling AK Address : Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Spain. Source : J Investig Allergol Clin Immunol, 9(1):6-13 1999 Jan-Feb Abstract
[techno-med spiel snipped] Therefore, a consequent treatment of the infection is required, by means of wide spectrum antibiotics, as well as prescription of bacterial immunotherapy, as we have emphasized on other occasions. In conclusion, we must try to cure asthmatic patients and not to maintain them with inhalers and unnecessary corticosteroid therapy, since increasing reactions to corticosteroids are witnessed every day.
Of course this will mean less revenue for the pharmo-fatcats if word gets round. I wish I could try a course of these antibiotics as steroids only make my asthma worse. Trouble is, the medical profession is so fixated on the fact that airway inflammation is caused by …er, well, who knows what really, and that steroids have been shown to be effective for a lot of people and therefore MUST be effective for me. So, it’s no to the antibiotics and yes to steroids, even if they are making me worse. Jo.
Response:
Title : Bacterial infection as an important triggering factor in bronchial asthma. Author : Oehling AK Address : Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Spain. Source : J Investig Allergol Clin Immunol, 9(1):6-13 1999 Jan-Feb Abstract It is very surprising that in recent decades, the bacterial infection factor has been so overlooked in the causal treatment of bronchial asthma. Emphasis is put in the viral infection, but the bacterial infection usually associated with it is ignored. In several publications, we have insisted on the importance of the bacterial infection factor in the etiopathogenesis of bronchial asthma. It is alarming that even in the international consensus on its treatment this aspect is overlooked. In the first decades of this century, great importance had already been put on bacterial infection in the triggering of bronchospasm. In this review, we insist on this role of bacterial infection, which comes as a result of our extensive experience in this area, and the fact that in the last 10 years many authors have proven its responsibility at a bronchial mucosa level. In due time, we may be able to prove that the bacterial antigens can potentiate the action of inhalant allergens. Some authors have even proven that the action of these bacterial antigens even more energetically increases the number of intraepithelial dendritic cells in the bronchial mucosa after inhalation of bacterial lipopolysaccharide. Bystander respiratory bacterial infections can also directly modulate T helper 1 and 2 selection parallel to the immune response to inhalant allergens. Recent studies have also proven that in respiratory infection, bacterial antigens hold the main responsibility in the inflammatory and bronchospastic response in the etiopathogenesis of bronchial asthma. Therefore, a consequent treatment of the infection is required, by means of wide spectrum antibiotics, as well as prescription of bacterial immunotherapy, as we have emphasized on other occasions. In conclusion, we must try to cure asthmatic patients and not to maintain them with inhalers and unnecessary corticosteroid therapy, since increasing reactions to corticosteroids are witnessed every day. Language : Eng Unique Identifier : 99229321 MESH Headings : Antigens, Bacterial IM ; Asthma IM/*MI/VI ; Bacterial Infections * ; Human Publication Type : JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL ISSN : 1018-9068 Country of Publication : SPAIN
Response:
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